Limited nucleotide pools restrict Epstein–Barr virus-mediated B-cell immortalization
نویسندگان
چکیده
منابع مشابه
Metabolic stress is a barrier to Epstein-Barr virus-mediated B-cell immortalization.
Epstein-Barr virus (EBV) is an oncogenic herpesvirus that has been causally linked to the development of B-cell and epithelial malignancies. Early after infection, EBV induces a transient period of hyperproliferation that is suppressed by the activation of the DNA damage response and a G1/S-phase growth arrest. This growth arrest prevents long-term outgrowth of the majority of infected cells. W...
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ژورنال
عنوان ژورنال: Oncogenesis
سال: 2017
ISSN: 2157-9024
DOI: 10.1038/oncsis.2017.46